Just as there are costs associated with many genes that offer an over- Jall benefit, there are costs associated with every major structural change preserved by natural selection. Walking upright gives us the ability to carry food and babies, but it predisposes us to back prob- lems. Many of the body’s apparent design flaws aren’t mistakes, just compromises. To better understand disease, we need to understand the hidden benefits of apparent mistakes in design.
O ur bodies were designed over the course of millions of years for Olives spent in small groups hunting and gathering on the plains of Africa. Natural selection has not had time to revise our bodies for coping with fatty diets, automobiles, drugs, artificial lights, and cen- tral heating. From this mismatch between our design and our envi- ronment arises much, perhaps most, preventable modern disease. The current epidemics of heart disease and breast cancer are tragic examples.
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