The relationships between hosts and parasites are so competitive, wasteful, and ruthlessly destructive that arms-race terminology offers an entirely appropriate framework for describing them. The rest of this chapter explains this point of view, but for an introduc- tion, just try to imagine the magnitude of the personal tragedy that infectious agents have caused throughout human history, until just a few decades ago. The mother of one of the authors (Williams) was orphaned at age nine by meningitis. He has a sister whose best friend died suddenly of acute appendicitis in fourth grade. Our micro- scopic enemies take no account of individual merit or importance. Shortly before Calvin Coolidge succeeded to the presidency of the United States, his sixteen-year-old son got a blister on his foot while playing tennis but bravely went on playing. The blister broke open and became infected, and in two weeks the boy was dead. As a result, the president of the United States was an ineffective emo- tional cripple (as even his admirers concede) throughout the ensuing campaign and his one term in office.
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