Dominant genes are another matter. If you have even one copy of a dominant gene that causes a disease, you get the disease and, on average, so will half your children. One of the best known such genes causes Huntington’s disease. Most people with this disease have no
symptoms until their forties, when their memory fades and their muscles begin to twitch. Some of their nerve cells steadily degenerate until these people cannot walk, remember their own names, or care for themselves. This disease is a particularly vivid example because of its devastating effects and because all known cases can be traced to a small number of European families in the 1600s. One of the men migrated to Nova Scotia. The gene and the disease have been passed on to hundreds of his descendants, including the folk singer Woody Guthrie. In the 1860s a Spanish sailor from Germany, Antonio Justo Doria, settled on the western shores of Lake Maracaibo in Venezuela. His descendants now form the greatest concentration of people with Huntington’s disease. Steady detective work and fabu- lous luck have enabled geneticists to pinpoint the Huntington’s gene on the short arm of chromosome 4.
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