For instance, our protection against cyanide depends on an enzyme called rhodanase, which adds a sulfur atom to cyanide to form a chemical called thiocyanate. Although thiocyanate is far less toxic than cyanide, it still prevents the normal uptake of iodine into thyroid tissue and thus can cause the overworked thyroid gland to enlarge-a condi- tion called goiter. Plants from the genus Brassica (including broccoli, Brussels sprouts, cauliflower, and cabbage) get their strong taste from allylisothiocyanate. The ability to taste a related compound, phenyl- thiocarbamate (PTC) varies greatly, as is well known by generations of students who have tasted a bit of PTC-impregnated filter paper as part of an experiment to demonstrate genetic variation. While some people can’t taste PTC, those with a different gene experience it as bitter. They may have an advantage in avoiding natural compounds that cause goi- ter. About 70 percent of individuals in most populations can taste PTC, but in the Andes, where such compounds are especially likely in the diet, 93 percent of the native people can taste it.
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