Excretion is the elimination of medications from the body, primarily through the kidneys. Elimination also takes place through the liver, lungs, intestines, and exocrine glands (such as in breast milk). Kidney dysfunction can lead to an increase in the duration and intensity of a medication’s response, so it is important to monitor BUN and creatinine levels.
MEDICATION RESPONSES Medication dosing attempts to regulate medication responses to maintain plasma levels between the minimum effective concentration (MEC) and the toxic concentration. A plasma medication level is in the therapeutic range when it is effective and not toxic. Nurses use therapeutic levels of many medications to monitor clients’ responses.
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